Charlotte gabel

Skip to main content. By using our site, you agree to our collection of information through the use of cookies. To learn more, view our Privacy Policy. Log In Sign Up. Add Social Profiles Facebook, Twitter, etc. Charlotte Gabel-jensen. Unfollow Follow Unblock. Other Affiliations:. Hydroxylated metabolites of midazolam identical to human metabolites were Besides phase I metabolites, a number of conjugated metabolites were detected using high-resolution mass spectrometry.

NMR analysis strongly suggested that the glycosylation occurred at the two nitrogens either one in each case of the imidazole ring.

Distribution of midazolam and the glucose conjuga Publication Date: Jan 24, Publication Name: Xenobiotica; the fate of foreign compounds in biological systems. Biochemistry and cell biology. The setup demonstrated that EME-MS can be used as a viable alternative to conventional protein precipitation followed by liquid chromatography-mass spectrometry LC-MS for studying drug metabolism.

Metabolism kinetics were investigated for three different drugs: amitriptyline, promethazine, and methadone. By comparing the EME-MS extraction profiles of the drug substances and formed drug metabolites with the metabolism profiles obtained by conventional protein precipitation followed by LC-MS good correlation was obtained with only very limited time delay in the extraction.

The results indicate th Chemical Engineering and Analytical Chemistry. The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D more. For decades, selenium research has been focused on the identification of active metabolites, which are crucial for selenium chemoprevention of cancer. In this context, the metabolite methylselenol CH3SeH is known for its action to In this context, the metabolite methylselenol CH3SeH is known for its action to selectively kill transformed cells through mechanisms that include increased formation of reactive oxygen species, induction of DNA damage, triggering of apoptosis, and inhibition of angiogenesis.

The expression of NKG2D ligands is induced by stress-associated pathways that occur early during malignant transformation and enable the recognition and elimination of tumors by activating the lymphocyte receptor NKG2D. However, the induction of cell surface expression was restricted to t Estimating intestinal absorption of inorganic and organic selenium compounds by in vitro flux and biotransformation studies in Caco-2 cells and ICP-MS detection more.

The aim of the present work was to compare and estimate absorption and biotransformation of selected selenium compounds by studying their fluxes across Caco-2 cells. Five different selenium compounds, selenomethionine SeMet , Selenium absorptive and exsorptive fluxes and accumulation in cell cytosol were analyzed by means of flow injection inductively coupled plasma mass spectrometry ICP-MS. Absorptive flux of SeMet, MeSeCys, and selenate showed values correlating to complete in vivo absorption, while selenite and MeSeA fluxes correlated to poor in vivo absorption.

Speciation analysis of cell l Publication Date: Publication Name: Biological trace element research. Quantification of pharmaceutical peptides using selenium as an elemental detection label more. Publication Date: Publication Name: Metallomics. Modelling concentration—analgesia relationships for morphine to evaluate experimental pain models more. The aim of this study was to develop population pharmacokinetic-pharmacodynamic models for morphine in experimental pain induced by skin heat and muscle pressure, and to evaluate the experimental pain models with regard to assessment of The aim of this study was to develop population pharmacokinetic-pharmacodynamic models for morphine in experimental pain induced by skin heat and muscle pressure, and to evaluate the experimental pain models with regard to assessment of morphine pharmacodynamics.

In a randomised, double-blind, placebo-controlled, crossover study, 39 healthy volunteers received an oral dose of 30mg morphine hydrochloride or placebo.

Non-linear mixed effects modelling was used to describe the plasma concentrations of morphine and metabolites, and the analgesic effect of morphine on experimental pain in skin and muscle. Baseline pain metrics varied between individuals and occasions, and were described with interindividual and interoccasion variability. Placebo-response did not change with time. For both pain metrics, morphine effect was proportional to baseline pain and was described with a linear model with interindividual variability on drug effect slope and linked to an effect compartment for muscle pressure.

The population pharmacokinetic-pharmacodynamic models developed in this study indicate that mechanical stimulation of muscle is a more clinically relevant pain stimulus for the assessment of morphine pharmacodynamics than thermal stimulation of skin.

Formation of methylselenol, dimethylselenide and dimethyldiselenide in in vitro metabolism models determined by headspace GC-MS more. The aim of this study was to identify the presence of MeSeH in metabolic reactions. An analytical method based on direct headspace GC-MS, eliminating loss of volatile species during sample pretreatment procedures, was developed for this Includes Address 5 Phone 6 Email 3. Resides in Erie, PA. Also known as Charlott Gabel.

Includes Address 1 Phone 1 Email 1. Resides in Cleveland, OH. Also known as C M Gabel. Includes Address 5 Phone 1. Resides in Nashville, TN. Related To Adam Gabel. Includes Address 7 Phone 3. Resides in Great Falls, MT. Lived In Cascade MT. Also known as Charl A Gabel. Includes Address 3 Phone 3. Resides in Brandamore, PA.

Also known as Charlotte R Gabelo. Includes Address 2 Phone 2. Resides in Leesburg, FL. Lived In Newark IL. Related To Edgar Gabel. Includes Address 5 Phone 2. Resides in New Holland, PA.